- SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS
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This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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- SPIRO COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
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This invention is directed to spiro-benzoisothiazole derivatives of formula (I), wherein j, k, m, q, Z, Q, R1, R2 and R3 are each as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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Page/Page column 82-83
(2008/06/13)
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