- Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity
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A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
- Ermann, Monika,Riether, Doris,Walker, Edward R.,Mushi, Innocent F.,Jenkins, James E.,Noya-Marino, Beatriz,Brewer, Mark L.,Taylor, Malcolm G.,Amouzegh, Patricia,East, Stephen P.,Dymock, Brian W.,Gemkow, Mark J.,Kahrs, Andreas F.,Ebneth, Andreas,Loebbe, Sabine,O'Shea, Kathy,Shih, Daw-Tsun,Thomson, David
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p. 1725 - 1729
(2008/12/20)
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- ARYLSULFONAMIDE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
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Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) and the formula (IA) wherein, R1, R2, R3, R4, R5/sup
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Page/Page column 37; 41
(2008/12/08)
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