Design, synthesis, and structure-activity relationships of a new series of α-adrenergic agonists: Spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)]
The contractions induced by a partial α1-adrenoceptor agonist in cutaneous veins, such as the saphenous vein, show a particular sensitivity to changes in local temperature: the contractility to a partial α1- adrenoceptor agonist incr