- CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS
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The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.
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Page/Page column 56; 63; 64
(2017/09/27)
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- Site selectivity of the diels-alder reactions of 3-[1-(tert-butyldimethylsilyloxy)vin-1-yl]furan and 3-(propen-2-yl)furan. Synthesis of 4-substituted benzofurans
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The Diels-Alder reaction of 3-vinylfurans 5 and 27 with DMAD, N-phenylmaleimide, and dimethyl maleate afforded products derived both from addition to the furan ring diene system (intraannular addition) and to the furan 2,3-double bond 3-vinyl group diene system (extraannular addition). For example, compounds 6 and 7 were obtained from 5 and DMAD. In contrast, dienophiles containing a phenylsulfinyl group, such as 19-21, gave products derived exclusively from the extraannular reaction mode. These products are useful precursors of 4-substituted benzofurans, especially 4-hydroxybenzofurans.
- Benítez, Aida,Herrera, F. Ruth,Romero, Margarita,Talamás, Francisco X.,Muchowski, Joseph M.
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p. 1487 - 1489
(2007/10/03)
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- On the Cycloaddition Approach to Indolocarbazoles
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2,2'-Biindolyl 9 reacts with electron-deficient dienophiles at 100-110 deg C to give low to moderate yields of Michael addition and formal cycloaddition products, with the former predominant; the products derived from 9 and 2-(phenylsulphinyl)maleimides 14 and 15 undergo in situ elimination of benzenesulphenic acid, leading to 2,2'-biindolyl-substituted maleimides which can be efficiently photocyclised into indolocarbazoles.
- Barry, John F.,Wallace, Timothy W.,Walshe, Nigel D. A.
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p. 12797 - 12806
(2007/10/02)
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