- Method for preparing dimethyl acetamidophthalate
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The invention relates to a method for preparing dimethyl acetamidophthalate. The method comprises the following steps: dissolving nitrophthalic anhydride in methanol, adding a graphite-phase carbon nitride supported cuprous catalyst (g-C3N4/Cu2O) and acetic anhydride, and carrying out reacting to obtain dimethyl acetamidophthalate. 200-300 mg of the graphite-phase carbon nitride supported cuprouscatalyst (g-C3N4/Cu2O) is used for every millimole of nitrophthalic anhydride, and 2.0-3.0 mmol of acetic anhydride is used for every millimole of nitrophthalic anhydride.
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Paragraph 0027-0028
(2020/08/22)
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- Preparation method for 3-aminophthalic acid and derivative thereof
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The invention discloses a preparation method for an apremilast intermediate, i.e., 3-aminophthalic acid, and a derivative thereof. The preparation method comprises a step of reducing 3-nitrophthalic acid or a derivative thereof in the presence of a reducing agent selected from a group consisting of elemental sulfur, sulfide and a mixture of elemental sulfur and sulfide. The method has the advantages of high yield, simple operation, environmental protection and suitability for industrial production.
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Paragraph 0022
(2017/04/11)
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- 3, 4-DI-SUBSTITUTED CYCLOBUTENE- 1, 2 -DIONES AS CXCR2 RECEPTOR ANTAGONISTS
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The present invention relates to compounds of formula (I) wherein R1, R2, Ar, p, R4 and R5 are as defined herein, which are useful for creating diseases which respond to CXCR2 receptor mediators. Pharmaceutical
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Page/Page column 45
(2010/06/20)
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- BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
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Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu- opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
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Page/Page column 27
(2009/01/20)
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- Comparable rates for cleavage of amide and ester bonds through nucleophilic attack by carboxylate anion and general acid catalysis by metal-bound water in a carboxypeptidase a model
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The kinetics of the Cu(II)- or Ni(II)-catalyzed deacylation of the methtyl ester (3) and the N,N-dimethyl amide (4) of 2-carboxy-6-[[2-(4-carboxymethyl)imidazolyl]azo]benzoate was measured in dimethyl sulfoxide containing 5% (v/v) water. Efficient catalys
- Suh, Junghun,Park, Tae Hoon,Hwang, Byung Keun
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p. 5141 - 5146
(2007/10/02)
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- Symmetrically Trisubstituted Triptycenes
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A simple synthesis of 1,8,13- and 1,8,16-trisubstituted triptycenes is described.Diels-Alder reaction of 1,8-disubstituted anthracenes with ortho-substituted benzynes gave 15 new triptycene compounds as mixtures of the syn (1,8,13) and anti (1,8,16) trisu
- Rogers, Miriam E.,Averill, Bruce A.
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p. 3308 - 3314
(2007/10/02)
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