An easy access to the exocyclic lactams analogous of the central nervous system active tricyclic nitroxapine, mianserine and chlothiapine agents using N-acyliminium chemistry
The conformationally restrained dibenzothia(oxa)zepines and dibenzazepines 4-6 analogous to the antidepressant Sintamil were prepared easily by π-cationic cyclization of the N-acyliminium ions 9A-C precursors with neat trifluoroacetic acid in three step-sequence starting from available amines and anhydrides. The regioselectivity in the reduction of imides especially in the maleimide derivatives as well as in the cyclization step was also discussed.
Hadou, Abderrahmane,Hamid, Abdulkareem,Mathouet, Hilarion,Deida, Mohamed-Fadel,Daich, Adam
scheme or table
p. 1017 - 1022
(2009/06/28)
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