- Synthesis method of trans-3-aminobutanol
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The invention discloses a method for synthesizing trans-3-aminobutanol, belongs to the field of organic chemical synthesis, and provides a novel method for synthesizing trans-3-aminobutanol in order to solve the problems of low safety, low yield, difficulty in obtaining a high-purity product and the like of an existing route. The method specifically comprises the following reaction steps: (1) carrying out mitsunobu reaction on a compound as shown in a formula II and carboxylic acid substances under the action of a condensing agent, and salifying to generate a compound as shown in a formula III; 2) hydrolyzing the compound shown in the formula III under an alkaline condition to obtain a compound shown in a formula IV; and 3) removing benzyl from the compound in the formula IV under the action of a catalyst to obtain the compound in the formula I. According to the invention, the method for synthesizing trans-3-aminobutanol is novel in process route, the total molar yield is greater than 70%, and the method has the characteristics of short route, high chemical purity and easiness in production.
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Paragraph 0013; 0026; 0031-0033; 0038-0039
(2021/04/07)
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- NEW PLEUROMUTILIN DERIVATIVE AND ITS USE
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The invention is directed to the L-tartrate salt of trans-3-aminocyclobutyl (lS,2R,3S,4S:,6R,7R,8R-,14R)-4-ethenyl-3-hydroxy-2,4,7, 14-tetramethyl-9- oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA.
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Page/Page column 13
(2010/11/27)
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