One-Pot Synthesis of Enantioenriched β-Amino Secondary Amides via an Enantioselective [4+2] Cycloaddition Reaction of Vinyl Azides with N-Acyl Imines Catalyzed by a Chiral Br?nsted Acid
A catalytic enantioselective synthesis of β-amino secondary amides was achieved using vinyl azides as the enamine-type nucleophile and chiral N-Tf phosphoramide as the chiral Br?nsted acid catalyst through a five-step sequential transformation in one pot.
A convenient one-pot approach to Paclitaxel (Taxol) side chain via 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines
An efficient cascade approach to α-hydroxy-β-amino acid derivatives is reported, which goes through a 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines and followed by hydrolysis under acidic conditions. This is the first example of using N-benzoylbenzyl imine as dipolarophile for 1,3-dipolar cycloaddition with carbonyl ylide, which provides a direct and convenient access for the one-pot synthesis of paclitaxel side chain and its derivatives.
Pyridylalanine (pal)-peptide catalyzed enantioselective allenoate additions to N-acyl imines
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Cowen, Bryan J.,Saunders, Lindsey B.,Miller, Scott J.
supporting information; experimental part
p. 6105 - 6107
(2009/09/26)
Modular synthesis of tetrasubstituted imidazoles and trisubstituted oxazoles by aldimine cross-coupling
A study was conducted to demonstrate the synthesis of tetrasubstituted imidazoles and trisubstituted oxazoles by aldimine cross-coupling reaction. The method involved 1,2-addition of easily available deprotonated N-monosubstituted α-aminotitriles to aldim
Kison, Coralie,Opatz, Till
body text
p. 843 - 845
(2009/06/28)
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