- Different properties of P,C-donor Pd(II) and Pt(II); spectroscopic and X-ray analysis, catalytic potential and anti-proliferative potency
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This account describes our recent studies on pallada-and platinaphosphacycle complexes with an unsymmetrical phosphonium ylide, Ph2PC(CH2)PPh2 = C(H)C(O)C6H4-p-NO2 (Y), derived from 1,1-bis(diphenylphosphino)ethylene (dppee). These complexes have been prepared through reactions between (Y) and [MCl2(cod)] (M = Pd (C1) or Pt (C2); cod = 1,5-cyclooctadiene) in equimolar ratio in the hope of finding new compounds that may be useful in stereoselective catalysis and find use as antitumor metallodrugs. Characterization of these compounds was performed by elemental analysis, IR, 1H, 13C, and 31P NMR spectroscopic methods. The structures of the Pd and Pt complexes were determined by single crystal x-ray structural analyses, showing that both complexes consist of five-membered rings formed by coordination of the phosphorus ylide (Y) through the phosphine group and the ylidic carbon atom to the metal center. The catalytic activity of the complexes, using the Mizoroki–Heck and Suzuki-Miyaura cross-coupling reactions, have been evaluated and compared. Moreover, both compounds have been found to have antitumor activity against AGS (gastric carcinoma), MCF-7 (breast carcinoma) and A549 (non-small lung carcinoma) cells with the average of IC50 values from 61.19 to 290.17 μM. Generally, C2 reveals high anticancer activity than C1.
- Yousefi, Abed,Sabounchei, Seyyed Javad,Moazzami Farida, Seyed Hamed,Karamian, Roya,Rahmani, Nosrat,Gable, Robert W.
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- Multifunctional supported bimetallic catalysts for a cascade reaction with hydrogen auto transfer: Synthesis of 4-phenylbutan-2-ones from 4-methoxybenzyl alcohols
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We report the one-pot tandem synthesis of 4-(4-methoxyphenyl)butan-2-one directly from 4-methoxybenzyl alcohol and acetone using a multifunctional supported AuPd nanoalloy catalyst. This one-pot synthesis involves dehydrogenation, aldol condensation and hydrogenation of CC. In this supported AuPd catalyst, the bimetallic sites catalyse the dehydrogenation and hydrogenation steps and, in combination with the support, catalyse the C-C coupling (aldol) process. This supported bimetallic catalyst is also effective in utilizing hydrogen from the dehydrogenation reaction for the hydrogenation of 4-(4-methoxyphenyl)but-3-en-2-one to 4-(4-methoxyphenyl)butane-2-one via a hydrogen auto transfer route. These multifunctional catalysts were characterised using transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy.
- Morad, Moataz,Nowicka, Ewa,Douthwaite, Mark,Iqbal, Sarwat,Miedziak, Peter,Edwards, Jennifer K.,Brett, Gemma L.,He, Qian,Morgan, David,Alshammari, Hamed,Bethell, Donald,Knight, David W.,Sankar, Meenakshisundaram,Hutchings, Graham J.
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p. 1928 - 1936
(2017/07/15)
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- Synthesis of α,β-unsaturated aryl esters via Heck reaction of unsymmetrical aryl tellurides
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A variety of α,β-unsaturated aryl esters were prepared by the direct reaction of unsymmetrical aryltellurides and ethyl acrylate, catalyzed by PdCl2 via a Heck cross-coupling reaction.
- Stefani, Hélio A.,Pena, Jesus M.,Gueogjian, Kemilla,Petragnani, Nicola,Vaz, Boniek G.,Eberlin, Marcos N.
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scheme or table
p. 5589 - 5595
(2011/02/22)
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- 1,4-benzoquinone: A new selective reagent for oxidation of alcohols
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The utility of 1,4-benzoquinone as a highly selective reagent for the oxidation of aryl conjugated primary allylic alcohols in the presence of benzylic and aryl conjugated secondary allylic alcohols is demonstrated. The reaction is clean, convenient and results in moderate to high yields.
- Kulkarni,Mathew
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p. 4497 - 4500
(2007/10/02)
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