- Direct indium-promoted preparation of α-methylene-γ-lactones from 2- (bromomethyl)acrylic acid and carbonyl compounds
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The reaction of 2-(bromomethyl)acrylic acid (2) with different carbonyl compounds 1 [CH2O, (E)-CH3CH=CHCHO, (i)PrCHO, (t)BuCHO, PhCHO, CH3(CH2)5CHO, c-C6H11CHO, Ph2CHCHO, (CH2)5CO, furfural, 1,4- cyclohexanedione, 2-chlorocyclohexanone, 2-hydroxybenzaldehyde, phthaldehyde, N-Boc-3-indolecarboxaldehyde, cholestanone, (1R)-(-)-myrtenal] and indium powder in a 1:1 THF:H2O mixture at room temperature affords, after acidic work-up with 6M hydrochloric acid, the corresponding α-methylene-γ-lactones 3.
- Choudhury, Prabir K.,Foubelo, Francisco,Yus, Miguel
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- Indium-promoted preparation of substituted α-methylene-γ-lactones from 2-(bromomethyl)acrylic acid and carbonyl compounds
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The reaction of 2-(bromomethyl)acrylic acid (1) with different carbonyl compounds (2) [CH20, (E)-CH3CH=CHCHO, Pr(i)CHO, Bu(t)CHO, PhCHO, CH3(CH2)5CHO, c-C6H11CHO, Ph2CHCHO, (CH2)5CO] and indium powder in a 1:1 THF:H20 mixture at room temperature affords, after acidic work-up with hydrochloric acid, the corresponding α-methylene-γ-butyrolactones 3.
- Choudhury, Prabir K.,Foubelo, Francisco,Yus, Miguel
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p. 3581 - 3584
(2007/10/03)
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