- Rearrangement of nitropyridylidenemalonate 1-oxides. A novel method for the synthesis of aminopyridine derivatives
-
Knoevenagel condensation between 3-nitro-2-pyridinecarbaldehyde and diethyl malonate catalyzed by titanium(IV) chloride gave diethyl 3-nitro-2-pyridylidenemalonate which was oxidized with peracetic acid to give corresponding 1-oxide. Reaction of the latte
- Wnuk, Stanislaw F,Lewandowska, Elzbieta,Valdez, Carlos A,Kinastowski, Stefan
-
-
Read Online
- Novel 3-azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity
-
Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3β which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.
- Ganser, Christopher,Lauermann, Eva,Maderer, Annett,Stauder, Torsten,Kramb, Jan-Peter,Plutizki, Stanislav,Kindler, Thomas,Moehler, Markus,Dannhardt, Gerd
-
p. 9531 - 9540
(2013/01/16)
-