Synthesis of pyridines from ketoximes and terminal alkynes via C-H bond functionalization
An expedient one-pot rhodium catalyzed C-H bond functionalization/ electrocyclization/dehydration procedure has been developed for the synthesis of highly substituted pyridine derivatives from terminal alkynes and α,β-unsaturated ketoximes. The use of electron-deficient phosphite ligands is important to suppress dimerization of the terminal alkynes to enynes.
Martin, Rhia M.,Bergman, Robert G.,Ellman, Jonathan A.
experimental part
p. 2501 - 2507
(2012/05/05)
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