- Cross-metathesis, a versatile synthetic methodology for the construction of alkenyl phosphine oxides and bis-phosphine oxides
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Substituted vinyl and allyl phosphine oxides have been prepared by olefin cross-metathesis providing exclusive E olefin stereochemistry. The methodology has been successfully extended to the preparation of various bis-phosphine oxides.
- Bisaro,Gouverneur
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p. 7133 - 7135
(2007/10/03)
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- SYNTHESIS OF SINGLE ISOMERS (E OR Z) OF PROTECTED γ,δ-UNSATURATED KETONES BY THE HORNER-WITTIG REACTION
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The lithium derivative of the γ-diphenylphosphinoyl ketal (10a) added to aldehydes and ketones to give stable Horner-Wittig intermediates (11) which were separated and converted into single isomers (E or Z) or γ,δ-unsaturated ketals (12). erythro-Adducts (11) and hence Z-(12), were selectively formed by addition of aldehydes and threo adducts (11), and hence E-(12), by reduction of the corresponding α-diphenylphosphinoyl ketones (13), prepared by acylation of the same γ-diphenylphosphinoyl ketal (10a).
- Cornish Christopher A.,Warren, Stuart
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p. 2585 - 2598
(2007/10/02)
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