- Structure-Activity Relationships of Kadsurenone Analogues
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Kadsurenone, a specific receptor antagonist of platelet-activating factor (PAF), and its analogues were prepared from derivatives of cinnamyl alcohol and (allyloxy)phenol.Racemic kadsurenone, resolvable by a Chiralpak column at low temperatures, has an IC50 value of 2 * 10-7 M, which is about 50percent of the activity of the natural product (IC50 = 1 * 10-7 M).The structural specificity of kadsurenone was further demonstrated by the low PAF-receptor-blocking activities of denudatin B, mirandin A, desallylkadsurenone, and the 2-epimer of kadsurenone.
- Ponpipom, Mitree M.,Bugianesi, Robert L.,Brooker, David R.,Yue, Bao-Zhen,Hwang, San-Bao,Shen, Tsung-Ying
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p. 136 - 142
(2007/10/02)
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