- Synthesis of oligo(ethylene glycol) toward 44-mer
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A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.
- Ahmed, Saleh A.,Tanaka, Mutsuo
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p. 9884 - 9886
(2007/10/03)
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- Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains
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A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2-CH2)nY (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.
- Loiseau, Francois A.,Hii, King Kuok,Hill, Alison M.
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p. 639 - 647
(2007/10/03)
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- A NOVEL, UNEQUIVOCAL SYNTHESIS OF POLYETHYLENE GLYCOLS
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Unequivocal synthesis of polyethyleneglycols is presented.The key step for this synthesis is the selective monobenzylation of oligoethyleneglycols by the phase transfer catalysis technique.
- Coudert, Gerard,Mpassi, Michel,Guillaumet, Gerald,Selve, Claude
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