- Synthesis of terfenadine carboxylate
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A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromo-phenyl)-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchange using t-BuLi and subsequently condensed with 4-[4-(hydroxydiphenylmethylpiperidin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.
- Patel, Sunil,Waykole, Liladhar,Repic, Oljan,Chen, Kau-Ming
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p. 4699 - 4710
(2007/10/03)
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