Water enhanced synthesis of gem-bisphosphonates via Rh(i) mediated 1,4-conjugate addition of aryl boronic acids to vinylidenebisphosphonate esters
A new synthetic method characterized by low environmental impact for the synthesis of a wide range of gem-bisphosphonates bearing aryl substituents in β position as potential anti-resorption species to contrast osteoporosis is reported. The pivotal role p
Bianchini, Giulio,Scarso, Alessandro,Chiminazzo, Andrea,Sperni, Laura,Strukul, Giorgio
p. 656 - 662
(2013/03/29)
gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity
New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume
Nguyen,Niesor,Bentzen
p. 1426 - 1433
(2007/10/02)
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