cas 1061353-68-1, SR2516 | Articles data

An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R4, Q, Z, r, and p are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with FAK overexpression, including proliferative diseases.

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Chemical Properties

Boiling Point: 654.0±55.0 °C(Predicted)

Density: 1.334±0.06 g/cm3(Predicted)

Solubility:≥50.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

PKA: 14.58±0.46(Predicted)

PSA: 87.75000

LogP: 5.39430

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