- METHOD OF PREPARING CHOLINE ALFOSCERATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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The present invention relates to a method for preparing choline alfoscerate. According to the method provided by the present invention, choline alfoscerate of high purity can be obtained in high yield, and a choline alfoscerate pharmaceutical formulation of excellent quality can be prepared using the same. In addition, the present invention is capable of obtaining high-purity choline alfoscerate in a high yield, as well as having excellent process efficiency as a preparation process is simple and short.COPYRIGHT KIPO 2021
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Paragraph 0090-0094
(2020/10/27)
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- Synthesis method for compound choline alfoscerate for promoting brain functions
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The invention discloses a synthesis method for a compound choline alfoscerate for promoting brain functions. The synthesis method comprises the following steps: (1) enabling calcium phosphorylcholinechloride to react with oxalic acid to generate precipitate of phosphorylcholine chloride and oxalic acid; (2) enabling the phosphorylcholine chloride prepared in the step (1) to react with an alkali in a solvent so as to obtain a salt of the phosphorylcholine chloride; and (3) enabling the salt of the phosphorylcholine chloride to react with propylene glycol, so as to obtain choline alfoscerate. Raw materials of the synthesis method for the compound choline alfoscerate for promoting brain functions are low in price, low in cost and easy to obtain, the synthesis method is short in synthesis path and high in yield, the obtained product is high in chemical purity, all reactions need no special production equipment, the obtained intermediate and final products need no column chromatography orcrystallization purification, the production cost can be lowered, industrial amplified production can be facilitated, a high-purity product can be provided for the market, and thus high economic benefits can be met.
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Paragraph 0023-0028
(2019/11/21)
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- Phosphorus chloride of alkali acid radical gallbladder method for preparing calcium salt
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The invention provides a preparation method of calcium phosphorylcholine chloride, and belongs to the technical field of preparing organic phosphorus compound intermediates. The preparation method comprises the following steps of: putting choline chloride and excess phosphorylation agent in a reaction kettle for a condensation reaction, wherein the obtained condensate liquid is phosphorylcholine chloride; firstly, dissolving phosphorylcholine chloride with water, then adding alum and excess calcium hydroxide to the aqueous solution of phosphorylcholine chloride, regulating the pH, generating crystals and precipitating, and carrying out filter pressing to obtain the clear filtrate; adding calcium chloride to the clear filtrate, concentrating until solid is separated out to obtain the concentrated solution, adding ethanol metered by weight to the concentrated solution, separating out crystals, freezing and filtering to obtain the filter cake, then washing the filter cake with ethanol, and drying to obtain the finished product calcium phosphorylcholine chloride. The preparation method provided by the invention has the advantages of saving the energy source, reducing the energy consumption, shortening the production period, improving the yield and reducing the production cost; the content of calcium phosphorylcholine chloride in the finished product is 99% to 102%; the preparation method meets the requirements of industrial green production.
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Paragraph 0043-0044
(2017/02/24)
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- CDP-Ethanolamine and CDP-Choline: One-pot synthesis and 31P NMR study
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Herein we report a one-pot multi-step synthesis of the cofactors CDP-Ethanolamine and CDP-Choline starting from cytidine 5′-monophosphate and using commercially available and/or easily prepared reagents. While studying the 31P NMR spectrum of CDP-Ethanolamine, an unexpected characteristic for a pyrophosphate diester was observed as it showed a singlet or two doublets depending upon the pH. Therefore, further NMR studies were undertaken to investigate the pH dependence of the peak splitting pattern and measure the acid dissociation constants of the compounds.
- Ghezal, Salma,Thomasson, Maggie S.,Lefebvre-Tournier, Isabelle,Périgaud, Christian,Macnaughtan, Megan A.,Roy, Béatrice
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supporting information
p. 5306 - 5310
(2015/01/16)
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- PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS
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Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.
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- A PROCESS FOR PREPARATION OF L-ALPHA-GLYCEROPHOSPHORYL CHOLINE
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The present invention relates to a process for preparing L-α- glycerophosphorylcholine by reacting phosphocholine chloride to R-(+)-glycidol. The present invention can prepare a compound of formula 1 in short reaction step and high yield.
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Page/Page column 9
(2008/06/13)
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