First Iridium-Catalyzed Highly Enantioselective Hydrogenation of β-Nitroacrylates
The first highly chemo- and enantioselective hydrogenation of β-nitroacrylates was accomplished with an iridium catalyst (Ir-4) with yields and enantioselectivities of up to 96% and 98% ee, respectively. The resulting α-chiral β-nitro propionates are attractive building blocks for the synthesis of chiral β2-amino acids, which are the core scaffolds of bioactive natural products, pharmaceuticals, and β-peptides.
Organocatalytic asymmetric transferhydrogenation of β-nitroacrylates: Accessing β2-amino acids
We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of β-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active β2-amino acids. Copyright
Martin, Nolwenn J. A.,Cheng, Xu,List, Benjamin
supporting information; experimental part
p. 13862 - 13863
(2009/02/06)
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