Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.
PYRROLOTHIENOPYRIMIDINES II. SYNTHESIS OF 4-AMINOPYRROLOTHIENO (AND ) PYRIMIDINES
Cyclization of the appropriate cyanothienylpyrrolylcarboxylic acid azides in boiling ortho-dichlorobenzene conducted to the corresponding aminopyrrolothienopyrimidines.
Rault, Sylvain,Effi, Yamien,Lancelot, Jean-Charles,Robba, Max
p. 575 - 578
(2007/10/02)
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