Convenient synthesis of heterocyclic compounds with dihydropyrano[3,4-b] pyridine scaffold
A general method for the preparation of various substituted dihydropyrano [3,4-b]pyridines is reported. The formation of pyranopyridine structure was achieved by a Polonovski rearrangement of pyridine N-oxide with acetic anhydride, giving 2-(acetoxymethyl)-pyridine followed by an hydrolyzed and an intramolecular Williamson ether formation.
Pacquelet, Sandrine,Blache, Yves,Kimny, Tan,Dubois, Marie-Aleth Lacaille,Desbois, Nicolas
p. 1092 - 1100
(2013/03/29)
TOPICAL FORMULATIONS
There is provided topical pharmaceutical compositions comprising compounds of formula (I) wherein R1, R2, R3 and X have meanings given in the description. These compositions can be used to treat microbial infections and to
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Page/Page column 89; 90
(2008/12/05)
USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
There is provided the use of compounds of formula (I), wherein R1 R2 R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided
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Page/Page column 88
(2008/06/13)
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