A convenient synthesis and crystal structure of disubstituted 1,2,3-triazoles having ether functionality
A series of 27 ether-linked 1,4-disubstituted 1,2,3-triazoles (8a–8z1) has been synthesized by 1,3 dipolar cycloaddition of 1-substituted-4-(prop-2-yn-1-yloxy)benzene (3a–3c) and aromatic azides (5a–5c, 7a–7f). The synthesized compounds were ex
Synthesis, antibacterial, and antioxidant activities of naphthyl-linked disubstituted 1,2,3-triazoles
Here, click synthesis of 15 naphthyl-linked disubstituted 1,2,3-triazoles has been carried out by the reaction between 1-(prop-2-yn-1-yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, s
1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of Estrogen-related receptor α
Estrogen-related receptor α is a potential candidate target for therapeutic treatment of breast cancer. We describe the discovery and structure-activity relationship study of a series of 1-phenyl-4-benzoyl-1H-1,2, 3-triazoles as novel suppressors of ERRα
Xu, Shilin,Zhuang, Xiaoxi,Pan, Xiaofen,Zhang, Zhang,Duan, Lei,Liu, Yingxue,Zhang, Lianwen,Ren, Xiaomei,Ding, Ke
p. 4631 - 4640
(2013/07/19)
REMOTE INTRAMOLECULAR FUNCTIONALIZATION OF ARYLNITRENIUM IONS: SYNTHESIS OF AMINO-DIHYDROPHENANTHRIDINES AND BENZOCHROMANS.
4-Aminobenzochroman (6) and 3-amino-5-acetyl-5,6-dihydrophenanthridine (9) are synthesized by intramolecular trapping of the delocalized nitrenium ions from 3-azidobenzyl phenyl ether and 3-azido-N-benzylacetanilide, respectively.On the other hand, no cyclization product is obtained from 3-azidophenyl benzyl ether, possibly owing to an ortho-effect exerted by the oxygen atom ortho to the developing ?-aryl cation.
Abramovitch, Rudolph A.,Cooper, Melanie M.,Jeyaraman, Ramasubbu,Rusek, Grzegorz
p. 3705 - 3708
(2007/10/02)
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