- Synthesis of Some New Substituted Mercaptotriazoles and Thiazolidones and Their Monoamine Oxidase Inhibitory and Anticonvulsant Properties
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A number of 4-aryl-5-aryloxymethyl-3-mercapto-1,2,4(H)-triazoles (IV) and 2-arylimino-3-aryloxyacetamido-4-thiazolidones (V) have been synthesized.Some of these compounds inhibit rat brain monoamine oxidase (MAO) in vitro at a final concentration of 1E-3 mol/litre, but are found to be inactive against pentylenetetrazole induced seizures in mice at a dose of 80 mg/kg.
- Husain, M. I.,Amir, Mohd,Singh, Eira
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p. 251 - 254
(2007/10/02)
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- Synthesis of some New Substituted Thiosemicarbazides and Triazoles as Possible Anticonvulsants
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Forteen 1-o/p-anisoxyacetyl-4-arylthiosemicarbazides and their corresponding 5-(o/p-anisoxymethyl)-4-aryl-3-mercapto-1,2,4(H)-triazoles were synthesized.Eight of these compounds, when screened against maximal electroshock and pentylenetetrazole-induced seizures in mice at a dose of 80 mg/kg were, however, found to be inactive.
- Husain, M. I.,Amir, Mohd.
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p. 317 - 319
(2007/10/02)
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