- Glucopyranosyl derivative and application thereof in medicines
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The invention relates to a glucopyranosyl derivative used as a sodium-dependent glucose transporter (SGLT) inhibitor, a medicinal composition containing the derivative, and an application of the derivative and the medicinal composition in medicines, and especially relates to the glucopyranosyl derivative represented by formula (I) or a pharmaceutically acceptable salt or all stereoisomers thereof, or the medicinal composition containing the derivative, and a use of the derivative and the medicinal composition in the preparation of medicines for treating diabetes and diabetes related diseases.
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Paragraph 0765; 0766; 0767; 0768
(2016/10/08)
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- MUSCARINIC AGONISTS
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The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
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- Molecular Desidn of Crown Ethers. 4. Syntheses and Selective Cation Binding of 16-Crown-5 and 19-Crown-6 Lariats
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A number of new lariat 16-crown-5 and 19-crown-6 ethers posesing a variety of single or double side arm(s) were synthesized, and their cation-binding abilities were evaluated by solvent extraction technique.In general, the extractabilities of the 16-crown-5 lariats for most mono- and divalent cations increased gradually with extending oxyethylene side arm.However, sodium and silver ions, which are best size fitted to the crown cavity, showed peac extractability/selectivity at a specific length of the donating side arm.The complexation stoichiometry is 1 : 1 forall cations employed as confirmed by measurement of the extraction equilibrium constants for the single-armed 16-crown-5 (3p).The tetrasubstituted pivot carbon is shown to be a reguirement for lariat 16-crown-5 to effect extra side-arm ligation, although the second side arm of lariat ether 3e seems ineffective in extractability enhancement with reference to the single-armed analogue 3p.By contrast, the corresponding 19-crown-5 lariat with potential donor side arms at an appropiate position did not show any enhancement in extractability for most cations, which may be attributed to its flexible framework.
- Ouchi, Mikio,Inoue, Yoshihisa,Wada, Kazuhito,Iketani, Shin-ichi,Hakushi, Tadao,Weber, Edwin
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p. 2420 - 2427
(2007/10/02)
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