- Preparation method of benzyl aryl ether and application of benzyl aryl ether in synthesis
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and, 6-dihydrodibenzo [11 - b] oxazepine e -11 - ketone compounds are synthesized through a one-step reaction of benzaldehyde compounds and phenolic compounds through one-step reaction. The benzyl aryl ether and 6 and 11 -dihydrodibenzo [b, e] oxazepine -11 - ketone compound respectively have a chemical structure formula shown in a formula I and II. The invention discloses a synthesis method of the compound. Benzaldehyde compound After completion of the reaction, I, 6-dihydrodibenzo [11 - b] oxazepine e ketone compound -11 - can be synthesized through an oxidation or hydrolysis step and a ring closing step after the reaction is complete II.
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Paragraph 0145-0150
(2021/09/01)
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- Green synthetic method of kresoxim-methyl
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The invention belongs to the technical field of fine chemical engineering, and particularly relates to a green synthetic method of kresoxim-methyl. The method comprises the following steps: carrying out nitrous nitrification by using 2-methylbenzyl cyanide as an initial raw material, carrying out methylation, carrying out hydrolytic methylation or hydrolytic esterification, carrying out bromination and carrying out an etherification reaction to obtain the high-content kresoxim-methyl. The method provided by the invention has a short reaction period, a high conversion rate, and excellent product quality, changes the defect that high-concentration hydrochloric acid gas is used for preparation in a traditional process, and has the advantages of simple operation steps, simple equipment, low energy consumption, a short period, high productivity and environmental protection.
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Paragraph 0085; 0086; 0087
(2019/11/13)
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- Iron(II) promoted direct synthesis of dibenzo[b,e]oxepin-11(6H)-one derivatives with biological activity. A short synthesis of doxepin
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A novel and efficient synthesis of dibenzo[b,e]oxepin-11(6H)-ones by direct intramolecular ortho-acylation from readily available 2-(phenoxymethyl)benzoic acids was developed. The method takes advantage of a newly developed cooperative system consisting of sustainable FeCl2 and Cl2CHOCH3 as the key components. This methodology is compatible with a wide variety of functional groups in good to excellent yields and high regioselectivity. The synthetic application of new protocol was extended to the synthesis of known tricyclic drug doxepin as well as a small library of oxepin based derivatives. For the first time, the obtained dibenzo[b,e]oxepinone derivatives were evaluated for their biological activities on the free-living nematode Caenorhabditis elegans as an effective and cost-efficient model system for anthelmintic discovery.
- Scoccia, Jimena,Castro, M. Julia,Faraoni, M. Belén,Bouzat, Cecilia,Martín, Víctor S.,Gerbino, Darío C.
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supporting information
p. 2913 - 2922
(2017/04/26)
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- Preparation apparatus and method of kresoxim-methyl intermediate
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The invention belongs to the technical field of organic synthesis and particularly relates to a preparation apparatus and method of kresoxim-methyl intermediate. The apparatus comprises a reactor, a condenser, a centrifuge, a material tank and a mass flow
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Paragraph 0035; 0036
(2016/12/16)
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- AN IMPROVED PROCESS FOR THE SYNTHESIS OF STROBILURIN FUNGICIDES VIZ TRIFLOXYSTROBIN AND KRESOXIM-METHYL
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The present invention relates to an improved process for the synthesis of E-isomer of compound of formula (5). It further relates to the conversion of formula (5), wherein R is H, to Intermediate (I) and subsequently to substantially pure Trifloxystrobin, compound of formula (I) in good yield.
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Page/Page column 37
(2013/10/21)
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- Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety
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A series of 2,4-disubstituted-[1,3]-thiazoles (4a-p and 6a-l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemen
- Naveena, Channamata Shankar,Poojary, Boja,Arulmoli, Thangavelu,Manjunatha, Kumshi,Prabhu, Ashwatanarayana,Kumari, Nalilu Sucheta
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p. 1925 - 1937
(2013/07/26)
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- Synthesis and biological evaluation of some [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
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The reaction of 2-(aryloxymethyl)benzoic acid hydrazide with carbon disulfide in the presence of potassium hydroxide followed by hydrazine hydrate afforded 4-amino-3{2-(aryloxymethyl)pheny}[1,2,4]triazole-5-thiol (5a-d). The cyclo-condensation of 5a-d with various aromatic carboxylic acids in the presence of phosphorous oxychloride and with phenacyl bromides afforded two series of fused heterocycles namely; 6-substituted-3-{2-(aryloxymethyl)phenyl}- 1,2,4- triazolo[3,4-b][1,3,4]thiadizoles (6a-t) and 6-substituted-3-{2- (aryloxymethyl)phenyl)}[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines (7a-p) respectively. The structures of these newly synthesized compounds were established on the basis of their IR, 1H-NMR 13C-NMR and Mass spectral data. All the title compounds were screened for their antimicrobial and antiinflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents.
- Naveenaa, Channamata Shankara,Poojary, Boja,Chandrashekhar, Chikkanna,Kumari, Nalilu Suchetha
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experimental part
p. 189 - 200
(2012/02/14)
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- Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety
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Disubstituted 1,3,4-oxadaiazoles (4a-z, 4a′-f′), Mannich bases (6a-p) and S-alkylated derivatives (7a-t) have been synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multi-step reaction sequence. The structures of new compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their in vitro antibacterial and antifungal activity and some of them exhibited good activity.
- Naveena, Channamata Shankara,Boja, Poojary,Kumari, Nalilu Sucheta
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experimental part
p. 4708 - 4719
(2010/11/16)
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- Preparation of E-oxime ethers of phenylglyoxylic esters
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E-oxime ethers of phenylglyoxylic esters of the formula I STR1 where X and Y are each halogen, C1 -C4 -alkyl, C1 -C4 -alkoxy or trifluoromethyl; m is an integer from 0 to 4; n is an integer from 0 to 3; are prepared.
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