Tetrahydroindoloquinazoline compounds and application thereof
The invention relates to tetrahydroindoloquinazoline compounds and application thereof. Structures of the compounds are shown as a general formula (I) shown in the specification. The compounds are used for (1) preparing medicines for treating cardiovascul
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Paragraph 0059; 0112-0113
(2020/03/06)
Efficient syntheses of polyannular heterocycles featuring microwave- accelerated Bischler-Napieralski reaction, stereoselective Heck cyclization, and Claisen rearrangement
We report the synthesis of the polyannular heterocyclic compounds 1-7. The polyannular systems in the target molecules have been obtained using stereoselective Heck reactions of suitable o-substituted iodoarenes. Additionally, the first report on microwave-accelerated Bischler-Napieralski reaction is disclosed, which has been used in the syntheses of heterocycles 1-3. The compound 7, bearing a quaternary stereogenic center, has been prepared through a stereo-controlled Claisen-Johnson rearrangement from a derivative of the allylic alcohol 25.
THE SYNTHESIS OF FUSED RING NITROGEN HETEROCYCLES VIA REGIOSPECIFIC INTRAMOLECULAR HECK REACTIONS
A series of palladium (and in some cases rhodium) catalysed regiospecific 5-exo-, 6-endo- and 6-exo-trig cyclisations of aryl iodides and vinyl bromides onto proximate alkenes or heteroaromatic rings (indole, pyrrole) lead to a wide variety of fused ring