An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones
3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.
Rizzo, John R.,Alt, Charles A.,Zhang, Tony Y.
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p. 6749 - 6751
(2009/04/06)
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