- Synthesis method of amide derivative
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The invention relates to the field of organic synthesis, and discloses a synthesis method of an amide derivative. The synthesis method comprises the following steps: generating glycidyl ether from alkyl alcohol and epoxy chloropropane under the actions of alkali and a catalyst, and carrying out aminolysis on the glycidyl ether and ethanolamine to obtain a secondary amine derivative; and carrying out aminolysis on the secondary amine derivative and alkyl carboxylic acid methyl ester to obtain the amide derivative. The synthesis method disclosed by the invention is simple, short in synthesis route, short in product production period and high in economic benefit, the total yield of the product is 45 to 55%, and the purity is up to 98%.
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- Preparation of amide derivatives
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PROBLEM TO BE SOLVED: To provide a method for producing an amide derivative of high purity having only a small amount of a diacyl compound.SOLUTION: Provided is a method for producing an amide derivative represented by a general formula (1), comprising the following steps (I) to (III). Step (I) is a step of obtaining a crude product (A) by subjecting a hydroxy amine derivative represented by a general formula (2) and a fatty acid ester represented by a general formula (3) in a raw material supply molar ratio, [(3)]/[(2)], of 1.00 or more and 1.06 or lower in the presence of a basic catalyst. Step (II) is a step of obtaining a crude product (B) by adding ethanol containing water in a ratio of 5 mass% or more but 8 mass% or less to the crude product (A) obtained in the step (I) in an amount of 0.15 mass times to 1.8 mass times and heat-treating the mixture at 55°C or more and 68°C or less for 0.5 hour or more and 3 hours or less. Step (III) is a step of subjecting the crude product (B) obtained in the step (II) to crystallization from an alcohol.
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Paragraph 0026
(2017/06/02)
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- Composition for treating keratinous materials comprising a cationic associative polyurethane polymer and a protecting or conditioning agent
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The invention concerns a composition for treating keratinous fibres, in particular human keratinous fibres such as hair, comprising in a physiologically acceptable medium, at least a protecting or conditioning agent, and further at least a cationic associative polyurethane polymer. The invention also concerns methods and devices using said composition.
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- Composition for treating keratinous materials comprising a cationic poly(alkyl) vinyllactam polymer and a protecting or conditioning agent
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The invention relates to a composition for treating keratin materials, in particular the hair, comprising, in a physiologically and in particular a cosmetically acceptable medium, at least one protecting or conditioning agent, and also at least one cationic poly(alkyl)vinyllactam polymer. These combinations make it possible to improve the deposition of the agent for protecting or conditioning the keratin materials and also the cosmetic properties.
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- External skin care preparation
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An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: STR1 wherein R1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R6 and R7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R8 denotes a group --CH2 CH2 OH, --CH2 COOH or --COCH3.
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- Amide derivative and external medicament comprising same
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An external medicament comprises a novel amide derivative represented by the following formula (I). STR1 The external medicament is applicable to both a pharmaceutical external medicament and a cosmetic composition, and it provides excellent improving and preventing effects for chapping of the skin.
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