- Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives
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A novel series of 4-pyrazolyl-1,8-naphthalimide derivatives have been designed and facilely synthesized. For anticancer activity in vitro, most of the compounds were found to be more toxic against human mammary cancer cells (MCF-7) than human cervical car
- Li, Shenghui,Xu, Shengjie,Tang, Yonghe,Ding, Shan,Zhang, Jinchao,Wang, Shuxiang,Zhou, Guoqiang,Zhou, Chuanqi,Li, Xiaoliu
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supporting information
p. 586 - 590
(2014/01/23)
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- Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents
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A series of novel N-arylpyrazole derivatives, 5a-5i, were achieved from substituted phenylacetic acid via Vilsmeier-Haack reaction, hydrolysis, condensation, and aromatic substitution reaction. Their chemical structures were confirmed by 1H NMR
- Li, Shenghui,Xu, Shengjie,Ding, Shan,Zhang, Jinchao,Wang, Shuxiang,Li, Xiaoliu
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p. 1459 - 1468
(2014/05/06)
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- Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them
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The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF3, CHF2, CH2F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.
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Page/Page column 78
(2008/06/13)
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- NEW EFFICIENT SYNTHESIS OF 3(5)-CARBOMETHOXY-4-ARYLPYRAZOLES FROM 3-ARYL-2,3-DEHYDROAMINO ACID DERIVATIVES
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3(5)-Carbomethoxy-4-arylpyrazoles can be easily obtained by aromatization with boron trifluoride etherate of 4-aryl-3-acetamido(or benzamido)-3-carbomethoxy-Δ1-pyrazolines synthesized by 1,3-dipolar cycloaddition of diazomethane with 3-aryl-2,3
- Catiela, Carlos,Villegas, M. Dolores Diaz de,Gainza, M. Pilar
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p. 165 - 172
(2007/10/02)
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