- AROMATIC COMPOUND
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Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
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Paragraph 0761; 0762
(2016/05/19)
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- Hydrogen bond catalyzed direct reductive amination of ketones
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A novel, biomimetic concept for the direct reductive animation of ketones is described that relies on selective imine activation by hydrogen bond formation. The mild, acid- and metal-free process requires only catalytic amounts of thiourea as hydrogen bon
- Menche, Dirk,Hassfeld, Jorma,Li, Jun,Menche, Gerd,Ritter, Antje,Rudolph, Sven
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p. 741 - 744
(2007/10/03)
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- The Chemistry of N-Substituted Benzotriazoles. Part 4. A Novel and Versatile Method for the Mono-N-alkylation of Aromatic and Heteroaromatic Amines
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Mono-N-alkylation of aromatic and heteroaromatic amines is achieved in high yield by NaBH4 reduction of the adducts formed from benzotriazole, aliphatic aldehydes and the amines.Reaction of the same adducts with Grignard reagents gives N-(secondary alkyl)arylamines.Carboxy groups need no protection and nitro groups are unaffected.Adenine is mono-N-alkylated in high yield.
- Katritzky, Alan R.,Rachwal, Stanislaw,Rachwal, Bogumila
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p. 805 - 810
(2007/10/02)
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