Synthetic LSD metabolite for preparing haptens used in an LSD metabolite immunoassay
A general method for the synthesis of OH-LSD and its analogs has been successfully developed. This method is convenient and efficient and allows preparation of a series of OH-LSD analogs with linkers attached at various (C-8, N-6 or N-1) positions.
-
Page/Page column title page; 2; sheet 1
(2008/06/13)
Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.
-
(2008/06/13)
More Articles about upstream products of 111295-09-1
