- A Cs2CO3-mediated simple and selective method for the alkylation and acylation of 3,4-dihydropyrimidin-2(1 H)-thiones
-
Alkyl and acyl derivatives of 3,4-dihydropyrimidin-2(1H)-thiones were synthesized in good to excellent yields in the presence of Cs2CO3, a mild base. The method evidences a selective S-alkylation when using acyl chlorides as efficien
- Putatunda, Salil,Chakraborty, Arijit
-
p. 1057 - 1064
(2014/12/10)
-
- Synthesis of Acetylated Dihydropyrimidine Analogues under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers
-
One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCI2.2H20 affords eight different substituted 3,4-dihydropyrimidine ones/ thiones. Further we prepared acetylated 3,
- Sati, Bhawana,Sati, Hemlata,Saklani, Sarla,Nargund, L. V. G.,Lamma, E. L.,Khaidem, Somila,Bhatt, Prakash Chandra
-
p. 1055 - 1059,5
(2020/08/24)
-
- Synthesis and Reactions of "Biginelli-Compounds". Part I
-
Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.
- Kappe, Christian Oliver,Roschger, Peter
-
-