- HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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Paragraph 00655; 00659; 00709
(2015/04/22)
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- HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS
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Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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Paragraph 001311; 001315
(2015/11/10)
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- p-Substituted Asymmetric Ureas and Medical Uses Thereof
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Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula I: or pharmaceutically acceptable salts thereof.
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Paragraph 0253; 0255
(2015/09/28)
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- 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS
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Anti-viral agents of compounds of Formula (I) : wherein A, Rx, Ry, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
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Page/Page column 26-27
(2008/12/08)
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- 2-Thioethenyl substituted carbapenem derivatives
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[Objective] An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP),
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Page/Page column 22
(2010/11/25)
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- INDOLE COMPOUNDS USEFUL AS IMPDH INHIBITORS
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Compounds having the Formula (I), are effective as inhibitors of IMPDH enzyme, wherein R3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R1, R2, R4, and R5 are as defined in the specificat
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Page column 42-43
(2010/02/04)
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- Palladium-Catalyzed Reactions of Terminal Acetylenes and Olefins with Halo-1,3-azoles
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The palladium-catalyzed reactions of 4-bromo- and 5-bromothiazoles, as well as 4-bromo and 5-bromooxazoles with terminal acetylenes gave ethynyl derivatives in 43-89percent yields, whereas the reactions of 2-bromothiazoles and iodo-N-methylimidazoles affo
- Sakamoto, Takao,Nagata, Hideo,Kondo, Yoshinori,Shiraiwa, Masafumi,Yamanaka, Hiroshi
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p. 823 - 828
(2007/10/02)
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