- Tunable porous organic crystals: Structural scope and adsorption properties of nanoporous steroidal ureas
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Previous work has shown that certain steroidal bis-(N-phenyl)ureas, derived from cholic acid, form crystals in the P61 space group with unusually wide unidimensional pores. A key feature of the nanoporous steroidal urea (NPSU) structure is that
- Natarajan, Ramalingam,Bridgland, Lydia,Sirikulkajorn, Anchalee,Lee, Ji-Hun,Haddow, Mairi F.,Magro, Germinal,Ali, Bakhat,Narayanan, Sampriya,Strickland, Peter,Charmant, Jonathan P. H.,Orpen, A. Guy,McKeown, Neil B.,Bezzu, C. Grazia,Davis, Anthony P.
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- SILYLATED AZULENYL NITRONE SPIN TRAPS AS CHROMOTROPIC SUPEROXIDE DETECTORS
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Silylated nitrones and methods of detecting and/or superoxide using silylated nitrones are disclosed herein.
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Page/Page column 44; 45
(2013/05/22)
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- A small molecule sensor for fluoride based on an autoinductive, colorimetric signal amplification reaction
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This article describes a small molecule reagent that is capable of detecting fluoride down to 0.12 mM (2.3 ppm) in water. The reagent reveals this level of fluoride through a novel autoinductive signal amplification reaction that produces an unambiguous colorimetric readout.
- Baker, Matthew S.,Phillips, Scott T.
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supporting information; experimental part
p. 3595 - 3599
(2012/06/18)
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- Methylenecyclopropane Rearrangement as a Probe for Free Radical Substituent Effects. σ·Values for Potent Radical-Stabilizing Nitrogen-Containing Substituents
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A series of nitrogen-containing 2-aryl-3,3-dimethylmethylenecyclopropanes have been prepared and rearrangement rates to the corresponding 2-arylisopropylidenecyclopropanes have been measured. These rates are dependent on the nature of the nitrogen-containing group in the para-position of the aryl group. Rearrangement rates have been used to calculate σ· values, which are a measure of the radical stabilizing ability of the substituent. Groups such as p-N=N-Bu-t, p-CH=N-Bu-t, p-NH2, p-CH=N-OH, and p-CH=N-OCH3, are "good" radical stabilizers. We have also classified groups such as p-CH=N-NMe2, p-N=N-Ph, p-N=N(O)-Bu-t, p-CH=N(O)-Bu-t, and p-CH=N-O- M+, which have an extraordinarily large radical stabilizing effect, as "Super Stabilizers". These substituents stabilize the transition state of the methylenecyclopropane rearrangement by extensive spin delocalization. In the case of the latter three substituents, nitroxyl type stabilization is proposed. Density functional calculations (B3LYP/6-31G*) have been carried out on a series of nitrogen-containing substituted benzylic radicals. Rates of the methylenecyclopropane rearrangement correlate with radical stabilization energies (ΔE) determined from an isodesmic reaction of substituted benzylic radicals with toluene. These calculations confirm substantial spin delocalization onto the nitrogen-containing substituents on the para-position of the benzylic radical.
- Creary, Xavier,Engel, Paul S.,Kavaluskas, Natasha,Pan, Li,Wolf, Allison
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p. 5634 - 5643
(2007/10/03)
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- Synthesis and Investigation of Effects of 2-amino>phenoxy>-2-methylpropionic Acids on the Affinity of Hemoglobin for Oxygen: Structure-Activity Relationships
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A series of 2-carbonyl>amino>phenoxy>-2-methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-4-(3,4,5-Trichloro
- Lalezari, Iraj,Lalezari, Parviz
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p. 2352 - 2357
(2007/10/02)
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