Iron(III)-catalyzed synthesis of selenoesters from α-amino carbonyl derivatives at room temperature
An Fe(III)-catalyzed efficient method has been developed for the synthesis of selenoester derivatives in high yields through the coupling of α-amino carbonyl/glycine derivatives and diselenides under ambient air. A library of benzoselenoate derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. Experimental results suggest that the reaction proceeds through a radical pathway. Operational simplicity, compatibility with various α-amino carbonyls and diselenides, high yields, fast reaction and mild reaction conditions are the notable advantages of this procedure. We have also shown the practical application of the synthesized selenoesters which is useful to generate peptide bonds in biological sciences.
A Convenient Preparation of Aryl Arylcarbonyl Diselenides
A novel method for the synthesis of aryl arylcarbonyl diselenides via the reaction of potassium areneselenocarboxylates with areneselenenyl bromides is described.