cas 111991-09-4, Nicosulfuron | Articles data

Articles about 111991-09-4Total 19 be found

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Nicosulfuron water-phase method synthesis process
The present invention relates to the technical field of pesticides, and provides a nicosulfuron water-phase method synthesis process, which comprises: S1, material feeding: adding 2-ethoxycarbonyl amino sulfonyl-N, N-dimethyl nicotinamide, 2-amino-4, 6-dimethoxypyrimidine, a phase transfer catalyst and a solvent to a reaction kettle, and starting stirring; S2, reacting at the temperature of 60-100 DEG C for 5-7 hours; and S3, discharging: centrifuging and drying to obtain the nicosulfuron. Through the technical scheme, the problems of complex process and poor product quality in the prior art are solved.
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Paragraph 0020-0031

(2021/04/14)

Method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide
The invention belongs to the technical field of nicosulfuron original medicine production, and particularly relates to a method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, wherein the method comprises the following steps: reacting tetramethoxypropane with ethyl cyanoacetate to generate 1-cyano-4-methoxy-1-ethoxycarbonyl-1,3-butadiene (cyanoene for short, the same below); reacting cyano alkene with hydrogen sulfide to generate ethyl 2-mercaptonicotinate (sulfydryl substance for short) in a closed-loop manner; reacting the sulfydryl substance with dimethylamine, and then carrying out oxychlorination reaction to obtain sulfonyl chloride; carrying out ammonolysis reaction on the sulfonyl chloride and ammonia gas to obtain sulfonamide; and reacting sulfonamide with solid light and pyrilamine to obtain the nicosulfuron. According to the method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, each reaction step is mild and controllable, process equipment is simple, the production cost is low, the product quality is good, three wastes are reduced, energy is saved, the production environment is improved, and the goal of carbon neutralization is favorably realized.
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(2021/10/05)

Preparation method of nicosulfuron
The invention discloses a preparation method of nicosulfuron. The method comprises the following steps: carrying out first reaction treatment on 2-sulfamoyl-N,N-dimethylformamide to obtain corresponding carbamate, and carrying out a second reaction on the carbamate and dimethoxyaminopyrimidine to obtain the nicosulfuron. On the basis of the prior art, by improving the technological process, the yield of the intermediate 2-sulfamoyl-N,N-dimethylnicotinamide is increased, that is, the yield of nicosulfuron can be effectively increased; and meanwhile, the adopted raw material 2-chloro-N,N-dimethylnicotinamide can effectively reduce the cost so as to meet the requirements of modern industrial production.
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Paragraph 0030-0033

(2020/07/02)

Preparation method of nicosulfuron crude drug
The preparation method, of the nicosulfuron crude drug comprises the following steps: synthesizing, isocyanate group sulfonyl - NNNN, N-dimethyl nicotinamide: triphosgene 2 - triethylamine and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials in, reaction to synthesize nicosulfuron-N, N-dimethylnicotinamide 0-80 °C and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials to synthesize nicosulfuron-N, N-dimethylaminopyridine as a main, raw material, and high yield; of nicosulfuron. 2 - The method provided by the invention comprises the following steps, synthesizing 2 - 2 -isocyanuric acid group, sulfonyl - NNNNor N-dimethylaminopyrimidinil in 0-100 °C reaction to form a nicosulfuron prodrug. by reacting. 2 - The preparation method comprises the following. steps, synthesizing nicosulfuron-N, N-dimethyl nicotinamide.
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Paragraph 0020; 0024; 0026; 0030; 0031; 0035

(2020/03/23)

Nicosulfuron crystalline hydrate as well as preparation method and application thereof
The invention provides nicosulfuron crystalline hydrate as well as a preparation method and the application thereof and belongs to the field of organic synthesis. The invention provides the nicosulfuron crystalline hydrate which has a good crystal form, does not absorb moisture or damp in the air, is good in stability and easy in drying and later processing, in addition, the product is high in chemical purity, uniform in granularity distribution and good in dispersibility, a preparation processed later is good in stability, rapid in disintegration speed, high in bioactivity, remarkable in quality advantage, free of phenomena of material moisture absorption and sticking in the process of drying, crushing, packaging and downstream preparation processing in production workshops, beneficial toclean production and preparation material blending uniformity, and in addition has the advantages of being simple and easy in production process, high in yield, low in cost, and the like.
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Paragraph 0050; 0051; 0064-0069

(2019/10/23)

Synthesizing technology and device for improving nicosulfuron purity
The invention relates to a synthesizing technology and device for improving nicosulfuron purity. The technology is characterized in that 3-[(N,N-dimethylaminocarbonyl)-2-pyridyl] sulfonylcarbamate, 4,6-dimethoxy-2-pyrilamine and methylbenzene are heated to condense; mixed steam of methylbenzene treated as a solvent in the reaction and ethyl alcohol produced in the condensation enters a condenser;the mixed solution of condensed methylbenzene and ethyl alcohol enters an absorbent storing tank; methylbenzene absorbed through the ethyl alcohol is heated through an absorbent, and then the methylbenzene is added to a reaction kettle; the reaction is stopped when the content of the ethyl alcohol in the mixed steam produced by the reaction kettle is less than 0.0005%; the mixed solution in the reaction is cooled and centrifuged to obtain nicosulfuron. According to the technology, the ethyl alcohol produced in the reaction can be quickly and effectively removed, and the reaction is promoted to forwards perform, thus the purity and the yield of nicosulfuron can be improved; and moreover, the methylbenzene treated as the solvent and taken out through the ethyl alcohol is recycled, so that more energy is saved; and the reaction cycle is greatly reduced through the design, and as a result, the production efficiency is improved.
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Paragraph 0013; 0014; 0015

(2018/03/24)

Synthesizing method of raw nicosulfuron
The invention provides a synthesizing method of raw nicosulfuron. The method includes: synthesizing N,N-dimethyl nicotinamide, oxidizing the N,N-dimethyl nicotinamide, performing the sulfonylation of2-carbamido-4,6-dimethoxy pyrimidine, and synthesizing the raw nicosulfuron. The synthesizing method is short in synthesizing route, low in cost, high in yield, mild in synthesizing conditions, capable of avoiding the use of high-toxicity and high-pollution raw materials such as phosphorus oxychloride, chlorine and phosgene, green and safe, and capable of achieving industrial production.
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Paragraph 0013; 0024; 0035-0038; 0043-0044; 0049-0050; 0055

(2018/10/19)

Synthesis process of nicosulfuron original medicine
The invention relates to a synthesis process of a nicosulfuron original medicine. In the method, 2-chloronicotinic acid is used as a raw material to synthesize an intermediate 2-sulfunylchloro-N,N-dimethyl nicotinamide, which is then reacted with amino pyrimidine to produce the nicosulfuron. The method has good atom economy and meanwhile avoids use of highly-toxic raw materials, such as phosgene, and expensive catalysts. The method has simple operations, is low in pollution and is low in cost; by means of continuous material feeding and continuous distillation, continuous synthesis of the nicosulfuron original medicine is achieved, and synthesis quality and yield of the nicosulfuron are greatly improved.
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(2017/08/29)

Nicosulfuron method for the preparation of
The invention discloses a nicosulfuron preparation method. According to the invention, in an organic solvent, 2-sulfonyl chloride-N,N-dimethyl nicotinamide and sodium cyanate are subjected to a reaction for 2-10h under stirring under the existence of organic alkali and under a temperature of 10-50 DEG C; 2-amino-4-dimethoxy pyrimidin is added, and a reaction is carried out for 0.5-5h under stirring under an environmental temperature, such that nicosulfuron is obtained. According to the invention, sodium cyanate is subjected to a reaction with 2-sulfonyl chloride-N,N-dimethyl nicotinamide to produce corresponding isocyanate, and isocyanate is subjected to a condensation reaction with 2-amino-4-dimethoxy pyrimidin. The synthetic route has the advantages of mild reaction condition, low cost, high yield, and high purity. The intermediate is not needed to be separated, and reaction period is short, such that the method is suitable for industrialized productions. The method also has the advantages of low toxicity and no environment pollution, such that the method satisfies a green chemistry principle.
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Paragraph 0023-0027

(2017/02/23)

METHOD FOR PRODUCING PYRIMIDINE COMPOUND
To provide a method for producing pyrimidine compound useful as an intermediate for agricultural chemicals or pharmaceuticals, which is simple in operation, presents high yield and produces only a small amount of by-products. The method comprises reacting a compound represented by the formula (I) with a compound represented by the formula (II) in the presence of a pyridine compound to produce a compound represented by the formula (III), a compound represented by the formula (IV) or their mixture.
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Page/Page column 16

(2011/01/11)

Method for producing a solid herbicide formulation
The invention relates to a method for producing a solid herbicide formulation containing a) a herbicide from the group of sulfonylurea, or the salts thereof which are useful in the agricultural domain, b) optionally at least one other herbicide, c) optionally a safener, and d) at least one formulation adjuvant. A suspension is formed in water, consisting of the sulfonylurea a), optionally at least one other herbicide b), optionally a safener c) and at least one formulation adjuvant d). The suspension is adjusted to a pH value between 6.5 and 8 by adding an acid or a base, and is then dried to obtain the solid formulation.
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(2008/06/13)

Non-aqueous or low-water suspension concentrates of mixtures of active compounds for crop protection
The invention relates to stable liquid and highly effective suspension concentrates comprisinga) one or more solid herbicidally active compounds from the group of the sulfonylureas in suspended form,b) one or more active compounds which are partially or completely dissolved in component c),c) an organic solvent or solvent mixture,d) one or more nonionic emulsifiers,e) optionally one or more ionic emulsifiers,f) optionally one or more thickeners or thixotropic agents and no water or up to 30 percent by weight of water in dissolved form.
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(2008/06/13)

Herbicidal mixtures having a synergistic effect
PCT No. PCT/EP96/03996 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Sep. 12, 1996 PCT Pub. No. WO97/10714 PCT Pub. Date Mar. 27, 1997A composition comprising at least one sulfonylurea of the formula I wherein R1 is substituted alkyl; halogen; a group ER6 (E=O, S or NR7); COOR8; NO2; S(O)oR9; SO2NR10R11; or CONR10R11; R2 is hydrogen, alkyl, alkenyl, alkynyl, halogen, alkoxy, haloalkoxy, haloalkyl, alkylsulfonyl, nitro, cyano or alkylthio; R3 is F, CF3, CF2Cl, CF2H, OCF3, OCF2Cl, or, if R1 is CO2CH3 and R2 is simultaneously fluorine, R3 is Cl, or, if R1 is CH2CF3 or CF2CF3, R3 is methyl, or, if R4 is OCF3 or OCF2Cl, R3 is OCF2H or OCF2Br; R4 is alkoxy, alkyl, alkylthio, alkylamino, dialkylamino, halogen, haloalkyl or haloalkoxy; and R5 is hydrogen, alkoxy or alkyl; or an enviromentally compatible salt of I, and an aryloxyalkanoic acid selected from the group consisting of 2,4-D, 2,4-DB, clomeprop, dichlorprop, dichlorprop-P, dichlorprop-P (2,4-DP-P), fenoprop (2,4,5-TP), fluoroxypyr, MCPA, MCPB, mecoprop, mecoprop-P, napropamide, napropanilide, triclopyr, and an enviromentally compatible salt thereof exhibits a synergistic herbicidal effect.
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(2008/06/13)

Mercapto-substituted pyridine compounds, aminocarbonyl-substituted pyridinesulfinic acid compounds and process for preparing the same
An aminocarbonyl-substituted pyridinesulfinic acid intermediate for production of an herbicide having formula (V): STR1 wherein R3 and R4 are selected from the group consisting of hydrogen and alkyl groups, or a salt thereof. The aminocarbonyl-substituted pyridinesulfinic acid or salt thereof is useful as the precursor of aminosulfonyl-substituted pyridinecarbonic acid amide, which in turn is useful as the starting material for agricultural chemicals, medicine, etc.
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(2008/06/13)

Mercapto-substituted pyridine compounds
A mercapto-substituted pyridine compound having formula (I): STR1 where R1 and R2 are alkyl groups, and n is 0 or 1, and salts thereof and a process for preparing the same are disclosed. The mercapto-substituted pyridine compound is useful as an intermediate for preparing a herbicidal compound. The present invention further provides aminocarbonyl-substituted pyridinesulfinic acid (ACPS) or salts thereof as the precursor of aminosulfonyl-substituted pyridinecarbonic acid amide compound (APCA) which is useful as the starting material for agricultural chemicals, medicine, etc. Moreover, the preparation process of the present invention is an industrially advantageous preparation process which is capable of preparing in a series of steps from mercapto-substituted pyridinecarboxylic acid amide compound (MPCA) or aminocarbonyl-substituted halogenopyridine compound (ACHP) to ACPS or salts thereof, and further to APCA.
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(2008/06/13)

Soybean plants with dominant selectable trait for herbicide resistance
The utilization of a positive selection seed screening process to isolate rate variants with resistance to a herbicide is described. The ability to screen large numbers of mutagenized seed has made it feasible to pursue and isolate plants with low frequency dominant herbicide-resistance mutations. The dominant herbicide resistance mutations are useful for many applications including expanding the utility of sulfonylurea herbicides for soybean weed control, production of F1 and F2 seeds, and as selectable markers for efficient seed purification.
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(2008/06/13)

N-phenylpyrrolidines
The 1-(3,5-bis-trifluoromethylphenyl)-2-thioxopyrrolidine-4-carboxylic acid derivatives of the formula I below are suitable for protecting crop plants against the phytotoxic action of herbicides and for regulating the plant growth. The 1-(3,5-bis-trifluoromethylphenyl)-2-thioxopyrrolidine-4-carboxylic acid derivatives are those of the formula I STR1 wherein A is --COOR1, --COSR1, --COO? M≈, --CONR2 R3 or --COCl; R1 is hydrogen, C1 -C4 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl; R2 and R3 independently of one another are hydrogen, C1 -C4 alkyl or C3 -C7 cycloalkyl; or R2 and R3 together with the nitrogen atom to which they are bonded are a saturated 3- to 7-membered heterocycle which can contain an additional hetero atom selected from the group comprising O, N and S and which is unsubstituted or up to trisubstituted by C1 14 C4 alkyl; and M≈ is the equivalent of an alkali metal cation or an alkaline earth metal cation or HN≈ (R2)3, and their isomers in optically pure or enriched form.
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(2008/06/13)

Herbicidal pyridine sulfonamides
(Aminosulfonyl)pyridine carboxamides are useful as agricultural chemicals. In particular, many compounds are useful as herbicides which show significant herbicidal activity on grasses and yet have the unexpected property of being safe to corn.
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(2008/06/13)

Herbicidal pyridine sulfonamides
N,N-dimethyl-2-(aminosulfonyl)-3-pyridine carboxamides are useful as agricultural chemicals. In particular, the compounds are useful as herbicides which show significant herbicidal activity on grasses and yet have the unexpected property of being safe to corn.
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(2008/06/13)

Chemical Properties

Appearance/Colour :White solid
Melting Point: 141-144 ºC
Boiling Point: 333.8°C at 760 mmHg
Flash Point:155.7°C
Density: 1.445 g/cm³
Storage Temp.:0-6°C
Vapor Pressure: 2.55E-05mmHg at 25°C
Refractive Index: 1.7000 (estimate)
PKA: pKa (25°): 4.6
PSA: 161.09000
LogP: 1.64570

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111991-09-4

Articles about 111991-09-4Total 19 be found

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Chemical Properties

Appearance/Colour :White solid

Melting Point: 141-144 ºC

Boiling Point: 333.8°C at 760 mmHg

Flash Point:155.7°C

Density: 1.445 g/cm³

Storage Temp.:0-6°C

Vapor Pressure: 2.55E-05mmHg at 25°C

Refractive Index: 1.7000 (estimate)

PKA: pKa (25°): 4.6

PSA: 161.09000

LogP: 1.64570

Global suppliers and manufacturers of 111991-09-4total 162 suppliers on LookChem

Article Database

111991-09-4

Articles about 111991-09-4Total 19 be found

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Chemical Properties

Appearance/Colour :White solid

Melting Point: 141-144 ºC

Boiling Point: 333.8°C at 760 mmHg

Flash Point:155.7°C

Density: 1.445 g/cm3

Storage Temp.:0-6°C

Vapor Pressure: 2.55E-05mmHg at 25°C

Refractive Index: 1.7000 (estimate)

PKA: pKa (25°): 4.6

PSA: 161.09000

LogP: 1.64570

Global suppliers and manufacturers of 111991-09-4total 162 suppliers on LookChem

Density: 1.445 g/cm³