Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols
A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
Flanagan, Mark E.,Brickner, Steven J.,Lall, Manjinder,Casavant, Jeffrey,Deschenes, Laura,Finegan, Steven M.,George, David M.,Granskog, Karl,Hardink, Joel R.,Huband, Michael D.,Hoang, Thuy,Lamb, Lucinda,Marra, Andrea,Mitton-Fry, Mark,Mueller, John P.,Mullins, Lisa M.,Noe, Mark C.,O'Donnell, John P.,Pattavina, David,Penzien, Joseph B.,Schuff, Brandon P.,Sun, Jianmin,Whipple, David A.,Young, Jennifer,Gootz, Thomas D.
scheme or table
p. 385 - 390
(2011/07/09)
MONOCARBAMS
The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, Rs, and R6 as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I)
Antibacterial activity is exhibited by 3-acylamino-2-oxoazetidines having in the 1-position an activating group of the formula STR1 wherein R is STR2 and R4 is STR3
Antibacterial activity is exhibited by 2-azetidinones having an acylamino substituent in the 3-position and having an activating group in the 1-position of the formula STR1
Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula STR1
-
(2008/06/13)
More Articles about upstream products of 112334-42-6