cas 1123661-15-3, 8-(Phenylmethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene | Articles data ｜lookchem

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1123661-15-3

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8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
The invention provides 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds of formula (I): wherein R2, R7, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
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Page/Page column 13

(2009/04/24)

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1123661-18-6
8-benzyl-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide

Chemical Properties

Boiling Point: 387.852 °C at 760 mmHg
Flash Point:188.366 °C
Density: 1.08g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PKA: 8.46±0.40(Predicted)
PSA: 21.70000
LogP: 3.91900

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