- A Simple and Clean Synthesis of Polysubstituted 2,6-Dicyanoanilines Catalyzed by KF/alumina
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A simple and clean synthesis of polysubstituted 2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenemalonodinitriles in ethanol catalyzed by KF/ alumina. Use of non-hazardous solid base as a catalyst,
- Jain, Shubha,Keshwal, Balwant S.,Rajguru, Deepika,Bhagwat, Vasant W.
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p. 712 - 715
(2013/03/29)
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- Synthesis and antiradiation activity of some sulfur containing thiophene derivatives
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Condensation of 2-(2,2-dicyano-1-methylvinyl)thiophene (2) with phenylhydrazine furnished the corresponding 2-(1-phenylhydrazonoethyl)-thiophene (4). Compound (4) was obtained also via reaction of (1) with phenylhydrazine. Reaction of (2) with amines gave 2-(2,2-dicyano-1-ethylamino or benzylamino-1 methylethyl)thiophene (5a,b). Treatment of (2) with elemental sulfur yielded directly the cyclised product 2-(5-amino-4-cyano-3-thienyl)thiophene (6). On the other hand refluxing (2) in pyridine with carbon disulfide gave the pyridine-1,3-dithione derivative (7). Condensation of (2) with phenyl isocyanate and/or phenyl isothiocyanate afforded 6-amino-4-(2-thienyl)-1,2-dihydro-2-oxo-1-phenylpyridine-5-carbonitrile (9) and/or 5-(2-thienyl)-2,7-dithioxo-3,8-N-phenyl-1,2,3,7,8-pentahydropyrido[2,3-d] pyrimidine-4-imine (11). Also the dicyano derivative (2) when reacted with cinnamonitrile (12) afforded the 2-(3-amino-2,4-dicyano-5-arylphenyl)-thiophenes (15a-d). Conversion of (15b) into the polyazanaphthalene (17) and (18) was affected via cyclocondensation with phenyl isocyanate and/or phenyl isothiocyanate. Compound (15a) showed promising antiradiation activity.
- Hassan,Ghorab,Nassar
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- NITRILES IN ORGANIC SYNTHESIS: A NOVEL SYNTHESIS OF 2-THIENYLBIARYLS
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A novel synthesis of 2-thienylbiaryls via the reaction of the 2-cyano-3-(2-thienyl)crotononitrile with cinnamonitriles is reported.The same products were also obtained from the reaction of 1,1-dicyano-2-thienyl-4-arylbuta-1,3-dienes with malononitrile or
- Elagamey, Abdel Ghani A.,Sofan, Mamdouh A.,Kandeel, Zaghloul E.,Elnagdi, Mohamed H.
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p. 1561 - 1565
(2007/10/02)
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