Enantioselective introduction of a benzenesulfonylmethyl substituent at an unactivated carbon atom via chemoenzymatic methods
Introduction of a benzenesulfonylmethyl group at the unactivated γ-carbon of carboxylic acid derivatives has been achieved through a combination of rhodium acetate catalysed carbenoid C-H insertion and baker's yeast mediated kinetic resolution. Access to
Maguire, Anita R.,Kelleher, Leonard L.
p. 7459 - 7462
(2007/10/03)
PREPARATION OF α-DIAZO-β-KETOSULFONES BY DIAZO-TRANSFER REACTION WITH AN IN SITU GENERATED AZIDINIUM SALT. A SAFE AND EFFICIENT PROCEDURE FOR THE DIAZO-TRANSFER REACTION IN NEUTRAL MEDIUM.
An efficinet and mild procedure is described for the preparation of α-diazo-β-ketosulfones using an azidinium salt generated in situ from relatively inexpensive and safe chemicals.The method is equally applicable to other CH2-acidic compounds.
Monteiro, H. J.
p. 983 - 992
(2007/10/02)
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