The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
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Page/Page column 473
(2021/09/11)
A Convenient Synthesis of Nicotinate Esters from 3-Cyanopyridones
A convenient synthesis of alkyl-substituted ethyl nicotinates 8 was devised, using 3-cyano-2(1H)-pyridones 4.These were converted to the corresponding 2-bromo-3-cyanopyridines 5 with boiling phosphorus tribromide.The resulting 5 were smoothly debrominated
Paine, John B.
p. 351 - 355
(2007/10/02)
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