- TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS PESTICIDES
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The present disclosure provides a novel triazolopyridine compound as represented by formula (I) or a salt thereof that controls pests: wherein, R1 and R3 independently represent hydrogen, or the like; R2 represents C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, or the like; R4, R5, R7, and R8 independently represent hydrogen, halogen, or the like; R6 represents C1-C6 haloalkoxy, or the like; and Z represents an oxygen atom, a sulfur atom, SO, or SO2.
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- COMPOUNDS FOR THE TREATMENT OF CANCER
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The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, and their use for the treatment and/or prophylaxis of diseases.
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- NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER
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The present invention relates to novel compounds showing an inhibitory effect on Mps-1 kinase, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
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- TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS
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The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
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- DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
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The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency.
- East, Stephen P.,White, Clara Bantry,Barker, Oliver,Barker, Stephanie,Bennett, James,Brown, David,Boyd, E. Andrew,Brennan, Christopher,Chowdhury, Chandana,Collins, Ian,Convers-Reignier, Emmanuelle,Dymock, Brian W.,Fletcher, Rowena,Haydon, David J.,Gardiner, Mihaly,Hatcher, Stuart,Ingram, Peter,Lancett, Paul,Mortenson, Paul,Papadopoulos, Konstantinos,Smee, Carol,Thomaides-Brears, Helena B.,Tye, Heather,Workman, James,Czaplewski, Lloyd G.
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scheme or table
p. 894 - 899
(2009/08/15)
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