N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.
Mukherjee, Shubhasish,Robinson, Carolyn A.,Howe, Andrew G.,Mazor, Tali,Wood, Peter A.,Urgaonkar, Sameer,Hebert, Alan M.,RayChaudhuri, Debabrata,Shaw, Jared T.
p. 6651 - 6655
(2008/09/17)
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