Synthesis of (+/-)-endo- and (+/-)-exo-Brevicomin via Ene Reaction of the Pummerer Rearrangement Product Derived from 4-Chlorophenyl Methyl Sulfoxide
(+/-)-endo- (4) and (+/-)-exo-Brevicomin (5) were synthesized by employing the ene-type reaction of 4-chlorophenylthiomethyl trifluoroacetate (2) as the key step.The ene product 7 was converted, via two steps, into the ketosulfone 9, whose epoxidation fol