METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP
To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s). A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.
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Page/Page column 9
(2010/11/19)
Thiocarbamoylation of amine-containing compounds: 1. The reaction of tetramethylthiuram disulfide with 3-amino-4-methylbenzoic acid
The reaction of 3-amino-4-methylbenzoic acid with tetramethylthiuram disulfide in DMF afforded 3-N,N-dimethylthioureido-4-methylbenzoic acid. Thermolysis or treatment of the latter with acidic reagents resulted in elimination of dimethylarnine to form 3-i
Van Boi, Luu,Korzha,Barba
p. 739 - 742
(2007/10/03)
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