- PCl3-mediated synthesis of green/cyan fluorescent protein chromophores using amino acids
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Convenient synthesis involving aromatic amino acids, acetyl chlorides, and anilines in the presence of phosphorous trichloride has been established for the rapid synthesis of functionalized imidazolinones. With all the starting materials which are commercially available, low cost and stable, the construction of the target products has been accomplished via tandem transformations involving a key C-N coupling process, leading to the formation of two C(sp2)-N, one C=N, and one C=C bonds.
- Singh, Thokchom Prasanta,Shunmugam, Raja
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- One-pot synthesis of phenylseleno N-acetyl α-amino acids: Supra-molecular self-assembling in organoselenium compounds
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A convenient one-pot synthesis of phenylseleno N-acetyl α-amino acids, PhSeCH2C(O)NHC(R)COOH (R = H (1), Me (2), PhCH2 (3), 4-HOC6H4CH2 (4) and CH2OH (5)) is reported. These compounds have been characterized by microanalyses, UV-Vis, IR and NMR (1H, 13C, 77Se) spectroscopy. The molecular structures of [PhSeCH2CONHCH2COOH] (1), [PhSeCH2CONHCH(CH2C6H4OH-4)COOH] (4) and [PhSeCH2CONHCH(CH2OH)COOH] (5) have been established by X-ray diffraction analyses. These compounds are associated in the solid state through hydrogen bonding to give supra-molecular self-assembled structures. Free radical scavenging activity of these compounds has also been evaluated by DPPH assay.
- Parashiva Prabhu,Phadnis, Prasad P.,Wadawale, Amey,Priyadarsini, K. Indira,Jain, Vimal K.
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p. 140 - 147
(2013/10/01)
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