- Preparation method of mycophenolate mofetil
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The invention discloses a preparation method of mycophenolate mofetil. The preparation method of the mycophenolate mofetil comprises the following step: carrying out Mitsunobu reaction on mycophenolic acid and morpholinoethanol under the effects of triphenylphosphine and diisopropyl azodicarboxylate (DIAD) to prepare the mycophenolate mofetil. In the method, the reaction conditions are gentle, the process is simple and convenient, the yield is high, and therefore, the mycophenolate mofetil is suitable for being produced industrially.
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Paragraph 0018-0025
(2017/09/02)
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- USAGE OF MYCOPHENOLATE MOFETIL OR SALT THEREOF IN PREPARING DRUG FOR RESISTING AGAINST INFLUENZA VIRUS
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The present invention relates to a use of mycophenolate mofetil or a pharmaceutically acceptable salt thereof in the manufacture of a medicament against influenza virus. The present invention also relates to a use of mycophenolate mofetil or a pharmaceutically acceptable salt thereof in the manufacture of a medicament against drug-resistant influenza virus strains. The present invention is further related to a method for treating influenza in a subject, comprising administering to said subject an effective amount of mycophenolate mofetil or a pharmaceutically acceptable salt thereof.
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Paragraph 0047
(2016/03/14)
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- PROCESS FOR PREPARATION OF MYCOPHENOLIC ACID, ITS SALT AND ESTER DERIVATIVES
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The present invention discloses an isolation and purification process for mycophenolic acid obtained from the fermentation process. Invention further discloses preparation of sodium salt of mycophenolic acid and mycophenolate mofetil from mycophenolic acid.
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Page/Page column 6
(2011/07/29)
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- METHOD FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL
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The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol followed by downstream processing in the presence of a chelating agent (formula (I)).
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Page/Page column 7
(2009/03/07)
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- PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL
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The present invention relates to an improved and efficient process for the preparation of Mycophenolate Mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of Mycophenolic acid or esters, or acid chlorides, or amides with metal salt of morpholino ethanol. A further aspect of the invention relates to the purification of Mycophenolate mofetil through salt formation and release of the free base which on recrystalized from suitable solvents to get highly pure Mycophenolate mofetil. The present invention provided a novel intermediate and process for preparation thereof. Also provided is new impurity of Mycophenolate mofetil and process for preparation thereof.
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Page/Page column 12
(2009/08/14)
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- IMPROVED PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL
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The present invention relates to an improved method of manufacturing mycophenolate mofetil. More particularly, the present invention relates to a method of manufacturing mycophenolate mofetil with high purity comprising : a)converting mycophenolate to an amine salt by reacting with an amine base; and b)reacting the resultant with a halogenating agent and 2-morpholinoethanol continuously.
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Page/Page column 9-10; 1/3; 3/3
(2009/09/05)
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- ISOLATION AND USE OF AMINE SALTS OF MYCOPHENOLIC ACID
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The present invention provides a method for the isolation of mycophenolic acid from a fermentation broth comprising the steps of: (a) Adding a water-immiscible solvent to said fermentation broth; (b) Separating the water-immiscible phase from the aqueous phase, and; (c) Adding an amine to the water-immiscible phase obtained in step (b). Furthermore, the present invention provides the use of mycophenolate amines in the preparation of mycophenolate esters, in particular mycophenolate mofetil, and mycophenolate salts, in particular mycophenolate sodium salt.
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Page/Page column 11
(2010/11/29)
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- Process for Preparation of Mycophenolate Mofetil
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The present invention provides a novel process for the preparation of mycophenolate mofetil, by heating mycophenolic acid with 2-morpholinoethanol in an organic solvent in the presence of drying agent.
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Page/Page column 2
(2008/12/07)
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- PROCESS FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL
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Invention provides an improved process for the preparation of Mycophenolate mofetil by reacting Mycophenolic acid with morpholino ethanol in presence of Dipyridyl carbonate.
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Page/Page column 4-5
(2008/06/13)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL
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A process of manufacturing mycophenolate mofetil comprising reacting an alkyl ester of mycophenolic acid, with 2-(4-morpholinyl) ethanol in the presence of a catalyst selected from a form of zinc selected from metallic zinc or at least one zinc salt or at least one zinc oxide, or a form of calcium selected from metallic calcium or at least one calcium salt or at least one calcium oxide.
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Page/Page column 8; 9
(2008/06/13)
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- Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
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Provided are processes for the preparation of mycophenolate mofetil and other esters of mycophenolic acid.
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Page/Page column 7
(2008/06/13)
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- PROCESS FOR THE PRODUCTION OF MYCOPHENOLATE MOFETIL
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The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.
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Page/Page column 17
(2010/02/11)
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- Process for making mycophenolate mofetil by transesterification
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A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.
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- MICROWAVE SYNTHESIS OF MYCOPHENOLATE
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A process for synthesis of a compound of formula (I) using microwave irradiation.
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