Organocatalytic Enantioselective Friedel-Crafts Alkylation of 1-Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate
An organocatalytic enantioselective Friedel-Crafts alkylation of a series of substituted 1-naphthol derivatives and activated phenols with ethyl trifluoropyruvate, catalyzed by a quinine-derived squaramide, is presented. Good yields and high to excellent enantioselectivities of the Friedel-Crafts alkylation products were obtained.
Montesinos-Magraner, Marc,Vila, Carlos,Blay, Gonzalo,Fernández, Isabel,Mu?oz, M. Carmen,Pedro, José R.