A concise synthesis of biaryl PDE4D allosteric modulators
The optimization and synthesis of biaryl PDE4D allosteric modulator D159687 was achieved on gram scale via a concise two-step process. The synthesis features sequential chemoselective Suzuki coupling reactions taking advantage of different reactivity prof
Dalby, Amy,Mo, Xuesheng,Stoa, Robert,Wroblewski, Nathaniel,Zhang, Zheng,Hagen, Timothy J.
supporting information
p. 2737 - 2739
(2013/06/05)
BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is
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Page/Page column 40
(2009/06/27)
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